L. Fernando

Jun 12, 2024 | pnas.org | Del Villar |L. Fernando |Jacob Vogel |Aaron F. Alexander-Bloch

Fueling the heartbeat: Dynamic regulation of intracellular ATP during excitation–contraction coupling in ventricular myocytesEdited by W.J. Lederer, University of Maryland, Baltimore, MD; received October 23, 2023; accepted May 14, 2024 by Editorial Board Member Mark T. NelsonSignificanceThe function of the heart is to pump blood through the systemic and pulmonary circulations. To do this, cardiac muscle requires ATP as an energy source.

Feb 6, 2024 | uvadoc.uva.es | L. Fernando

The accepted role of the protein Kv2.1 in arterial smooth muscle cells is to form K+ channels in the sarcolemma. Opening of Kv2.1 channels causes membrane hyperpolarization, which decreases the activity of L-type CaV1.2 channels, lowering intracellular Ca2+ ([Ca2+]i) and causing smooth muscle relaxation. A limitation of this model is that it is based exclusively on data from male arterial myocytes.

Feb 6, 2024 | uvadoc.uva.es | L. Fernando

Por favor, use este identificador para citar o enlazar este ítem:https://uvadoc.uva.es/handle/10324/65821 Título A stochastic model of ion channel cluster formation in the plasma membrane Documento Fuente J Gen Physiol. 2019 Sep 2;151(9):1116-1134. Resumen Tipo de versión info:eu-repo/semantics/draft

Feb 6, 2024 | uvadoc.uva.es | L. Fernando

TRPV4 (transient receptor potential vanilloid 4) channels are Ca2+-permeable channels that play a key role in regulating vascular tone. In arterial myocytes, opening of TRPV4 channels creates local increases in Ca2+ influx, detectable optically as "TRPV4 sparklets." TRPV4 sparklet activity can be enhanced by the action of the vasoconstrictor angiotensin II (AngII).