Lalit Sehgal

Oct 2, 2024 | nature.com | Chinmayee Goda |Ozlen Balcioglu |Lalit Sehgal |Bin Zhang |Guido Marcucci |Elaine R. Mardis | +4 more

AbstractLeukemias arise from recurrent clonal mutations in hematopoietic stem/progenitor cells (HSPCs) that cause profound changes in the bone marrow microenvironment (BMM) favoring leukemic stem cell (LSC) growth over normal HSPCs. Understanding the cross talk between preleukemic mutated HSPCs and the BMM is critical to develop novel therapeutic strategies to prevent leukemogenesis. We hypothesize that preleukemic-LSCs (pLSCs) induce BMM changes critical for leukemogenesis.