Lars Plate

1 month ago | mdpi.com | Valeria Lopez |Valeria López |Lars Plate |Garcia Lopez

1. IntroductionSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a member of the Coronaviridae family, is responsible for the COVID-19 pandemic. Throughout the progression of the pandemic, the SARS-CoV-2 genome has undergone mutations that have led to changes in virulence, pathogenicity, and host immune evasion [1,2,3,4,5,6]. Coronavirus genomes typically range from 26 to 32 kilobases, making them among the largest RNA virus genomes.

Jun 3, 2024 | biorxiv.org | Jonathan Davies |Lars Plate

AbstractCoronaviruses (CoV) rewire host protein homeostasis (proteostasis) networks through interactions between viral nonstructural proteins (nsps) and host factors to promote infection. With the emergence of SARS-CoV-2, it is imperative to characterize host interactors shared across nsp homologs.

Mar 28, 2024 | medschool.vanderbilt.edu | Lars Plate

Sean Davies, associate professor of pharmacology and associate director of graduate studies for the department, has been awarded a Scaling Success grant from Research Development and Support in the Office of the Vice Provost for Research and Innovation.

Jan 24, 2024 | onlinelibrary.wiley.com | Minsoo Kim |Lars Plate

Conflict of interest No conflicts to declare. References 1, Am. J. Dis. Child. 1938, 56, 344–399. 2, , , , , , , , , , , , , , , , , , , , , , , , Science (80-. ). 1989, 245, 1066–1073. 3, , , Nature 2006, 440, 477–483. 4Cystic Fibrosis Foundation Patient Registry 2021 Annual Data Report, 2022, https://www.cff.org/media/23476/download. 5, , , , , , , , , , , , , , , , , , , , , , , , , , N. Engl. J. Med. 2010, 363, 1991–2003. 6, , , , , , , , , , , , , , Proc. Natl. Acad. Sci.