Laura K. Ferris

Jul 16, 2024 | biorxiv.org | Laura K. Ferris |Alicia R. Mathers

AbstractTrm cells are sequestered at barrier tissues as a swift first line defense against peripheral reinfections in both antigen dependent and antigen independent bystander modes. Trm cells are also capable of mediating autoimmune diseases, such as psoriasis, wherein autoreactive Trm cells are aberrantly activated. To quickly combat infections, activated Trm cells can stimulate the influx and activation of memory T cells and innate immune cells.

Feb 7, 2024 | nejm.org | Robert Bissonnette |Andreas Pinter |Laura K. Ferris |Ronald Vender

February 8, 2024N Engl J Med 2024; 390:510-521 DOI: 10.1056/NEJMoa2308713 AbstractThe use of monoclonal antibodies has changed the treatment of several immune-mediated inflammatory diseases, including psoriasis. However, these large proteins must be administered by injection. JNJ-77242113 is a novel, orally administered interleukin-23–receptor antagonist peptide that selectively blocks interleukin-23 signaling and downstream cytokine production.