Laura Tronci

Mar 8, 2023 | nature.com | Vincent Roberto Zecchini |Gonçalo Pereira |Laura Tronci |Shamith A. Samarajiwa |Thomas Mitchell |Julien Prudent | +1 more

AbstractMutations in fumarate hydratase (FH) cause hereditary leiomyomatosis and renal cell carcinoma1. Loss of FH in the kidney elicits several oncogenic signalling cascades through the accumulation of the oncometabolite fumarate2. However, although the long-term consequences of FH loss have been described, the acute response has not so far been investigated. Here we generated an inducible mouse model to study the chronology of FH loss in the kidney.