Laure Maneix

Dec 3, 2024 | digitalcommons.library.tmc.edu | Shannon E. Moree |Laure Maneix |Polina Iakova |Fabio Stossi

KeywordsOTUB1, c-MYC, ubiquitin–proteasome system, deubiquitinating protease, genetic screen, high-content imaging, deubiquitinase, protein turnover, oncogene, protein degradationAbstractThe ubiquitin-proteasome pathway precisely controls the turnover of transcription factors in the nucleus, playing an important role in maintaining appropriate quantities of these regulatory proteins. The transcription factor c-MYC is essential for normal development and is a critical cancer driver.

Nov 14, 2024 | digitalcommons.library.tmc.edu | Laure Maneix |Polina Iakova |Charles Lee |Shannon E. Moree

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