Lauren McGough

Apr 14, 2024 | nature.com | Lauren McGough |Rama Ranganathan

AbstractProteins are molecular machines and to understand how they work, we need to understand how they move. New pump-probe time-resolved X-ray diffraction methods open up ways to initiate and observe protein motions with atomistic detail in crystals on biologically relevant timescales. However, practical limitations of these experiments demands parallel development of effective molecular dynamics approaches to accelerate progress and extract meaning.

Jan 4, 2024 | biorxiv.org | Lauren McGough |Sarah Cobey

AbstractMany pathogens evolve to escape immunity, yet it remains difficult to predict whether immune pressure will lead to diversification, serial replacement of one variant by another, or more complex patterns. Pathogen strain dynamics are mediated by cross-protective immunity, whereby exposure to one strain partially protects against infection by antigenically diverged strains.

May 19, 2023 | projectupland.com | Lauren McGough

For thousands of years, trained golden eagles and sighthounds— sleek sinewy dogs built for speed and endurance—have worked together in pursuit of hare and foxes. In Mongolia, among the Kazakh people of the Altai mountains, there is an ancient poem that lists the things every true nomad should have. Chief among these are a “brave eagle” and a “swift dog.” Of course, a fast horse and a loyal wife are important too, but there is a reason that eagles and dogs win the top spots.