Lauren Porter

1 month ago | onlinelibrary.wiley.com | Joseph Schafer |Lauren Porter

1 INTRODUCTION AlphaFold2 (AF2) is a deep-learning-based algorithm that predicts a protein's three-dimensional structure from its amino acid sequence, often with high accuracy (Jumper et al., 2021).

Oct 15, 2024 | biorxiv.org | Joseph Schafer |Lauren Porter

AbstractAlphaFold2 (AF2), a deep-learning based model that predicts protein structures from their amino acid sequences, has recently been used to predict multiple protein conformations. In some cases, AF2 has successfully predicted both dominant and alternative conformations of fold-switching proteins, which remodel their secondary and tertiary structures in response to cellular stimuli.