Laurence H. Klotz

Jan 16, 2025 | nature.com | Laurence H. Klotz |Andrew Loblaw

AbstractWe sought to determine, in a prospective long term cohort, the prognostic value of negative MR imaging with respect to upgrading and need for intervention in men on AS. A long term prospective single centre study of men on Active surveillance with MR imaging. Primary outcome was upgrading on biopsy and rate of intervention. After incorporation of MRI into the AS protocol in 2013, men with negative imaging underwent systematic biopsy only for cause.

Jul 24, 2024 | urotoday.com | Laurence H. Klotz

Read the Full Video TranscriptLaurence Klotz: Missed windows of opportunity was my topic. So when does active surveillance break down in the real world? Goals are to avoid unnecessary treatment, and identify those who would benefit from treatment while they're still curable. So there's two sides to this. Unnecessary treatment due to overgrading, patient anxiety, and so on.

Jun 26, 2024 | nature.com | Laurence H. Klotz

AbstractThe use of systematic biopsies in addition to targeted biopsies is based on multiple studies showing that 15–20% of “clinically significant” cancers are missed on targeted biopsies. Concern about these ‘missed’ cancers drives many interventions. This includes systematic biopsies in men with negative imaging and in men having targeted biopsies, and drives a preference for total gland treatment in men who may be candidates for partial gland ablation.

Apr 12, 2024 | healthing.ca | Laurence H. Klotz

by Laurence Klotz Share This Story Healthy Debate: Prostate cancer screening guideline reflects lack of knowledgeable expert input This story originally appeared in Healthy Debate. The last guideline on prostate-cancer screening was published in 2014. At the time, the [Canadian Task Force on Preventive Health Care] approached the Canadian Urologic Association (CUA) and asked that it provide an expert panel of “stakeholders” to provide input.

Apr 10, 2024 | cuaj.ca | David-Dan Nguyen |Ahmad Mousa |Laurence H. Klotz |Tamim Niazi

Nguyen, D.-D., Mousa, A., Klotz, L., Niazi, T., Pouliot, F., Kokorovic, A., Lavallée, L. T., Huynh, M., Lapointe, N., Di Risio, M., & Wallis, C. J. (2024). Screening and management of metabolic, cardiac, and bone health in prostate cancer patients on androgen deprivation therapy: A survey of specialized physicians. Canadian Urological Association Journal, 18(8). https://doi.org/10.5489/cuaj.8687