Laurent Gatto

Feb 9, 2024 | jbc.org | Laurent Gatto |Bioinformatics Unit |Philippe P. Roux

AbstractThe p90 ribosomal S6 kinases (RSK) family of serine/threonine kinases comprises four isoforms (RSK1-4) that lie downstream of the ERK1/2 mitogen-activated protein kinase (MAPK) pathway. RSKs are implicated in fine tuning of cellular processes such as translation, transcription, proliferation, and motility. Previous work showed that pathogens such as Cardioviruses could hijack any of the four RSK isoforms to inhibit PKR activation or to disrupt cellular nucleocytoplasmic trafficking.

Mar 2, 2023 | nature.com | Laurent Gatto |Ruedi Aebersold |Juergen Cox |Vadim Demichev |Jason Derks |Edward Emmott | +7 more

The goal of reporting is to enable other researchers to repeat, reproduce, assess and build upon published data and their interpretation79. While reproduction and replication do not guarantee accuracy, they build trust in the analysis process through verifiability, thus strengthening confidence in the reported data and results.