Laurent Peyrin-Biroulet

Jan 31, 2025 | nature.com | Laurent Peyrin-Biroulet

AbstractInflammatory bowel disease (IBD), encompassing ulcerative colitis and Crohn’s disease, is a group of chronic, immune-mediated disorders of the gastrointestinal tract that present substantial clinical challenges owing to their complex pathophysiology and tendency to relapse. A treat-to-target approach is recommended, involving iterative treatment adjustments to achieve clinical response, reduce inflammatory markers and achieve long-term goals such as mucosal healing.

May 24, 2024 | mdpi.com | Ferdinando D’Amico |Laurent Peyrin-Biroulet |Silvio Danese

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Apr 24, 2024 | mdpi.com | Ferdinando D’Amico |Vipul Jairath |Kristine Paridaens |Laurent Peyrin-Biroulet

All articles published by MDPI are made immediately available worldwide under an open access license. No specialpermission is required to reuse all or part of the article published by MDPI, including figures and tables. Forarticles published under an open access Creative Common CC BY license, any part of the article may be reused withoutpermission provided that the original article is clearly cited. For more information, please refer tohttps://www.mdpi.com/openaccess.

Jan 5, 2024 | nature.com | Silvio Danese |Laurent Peyrin-Biroulet

A substantial percentage of patients with inflammatory bowel disease (IBD) exhibit biologic treatment failure or loss of response over time. This article explores the effectiveness and safety of monoclonal antibodies targeting the IL-23 pathway in treating IBD; continued research is needed to address lingering questions regarding long-term safety and efficacy.