Leighton Lee

Nov 28, 2024 | biorxiv.org | Emma Murray |Leighton Lee |Cameron Mitchell |Gilian M. Hodge

AbstractThe organization of the cell′s cytoskeletal filaments is coordinated through a complex symphony of signaling cascades originating from internal and external cues. Two major actin regulatory pathways are signal transduction through Rho family GTPases and growth and proliferation signaling through the Hippo pathway. These two pathways act to define the actin cytoskeleton, controlling foundational cellular attributes such as morphology and polarity.