Lena Zeller

Jun 24, 2024 | biorxiv.org | Michael Barnett |Lena Zeller |Paul B. Rainey

AbstractCapacity to generate adaptive variation can evolve by natural selection. However, the idea that mutation becomes biased toward specific adaptive outcomes is controversial. We report the de novo evolution of enhanced evolvability in experimental populations of bacteria. Key to realisation was a lineage-level birth-death dynamic, where lineage success depended upon capacity to mutate between two phenotypic states, each optima in a cycling environment.

May 7, 2024 | biorxiv.org | Michael Barnett |Lena Zeller |Paul B. Rainey

AbstractIt has been proposed that capacity to generate variation can evolve by natural selection such that mutation becomes biased toward adaptive outcomes. However this idea has remained largely theoretical. Here we detail the de novo evolution of evolvability in experimental populations of bacteria, making explicit the selective processes and molecular events.

May 3, 2024 | biorxiv.org | Michael Barnett |Paul B. Rainey |Lena Zeller

AbstractIt has been proposed that capacity to generate variation can evolve by natural selection such that mutation becomes biased toward adaptive outcomes. However the idea that selection might drive the evolution of evolvability has remained largely theoretical. Here we detail the de novo evolution of evolvability in experimental populations of bacteria, making explicit the selective processes and molecular events.