Leon Matthews

Jun 27, 2024 | digitalcommons.library.tmc.edu | Laura Cunningham |Sourabh Mishra |Leon Matthews |Stephen Fletcher

We report a general, catalyst-controlled route to prostaglandin F2α and its analogues. The approach uses a Rh-catalyzed dynamic kinetic asymmetric Suzuki–Miyaura coupling reaction between a racemic bicyclic allyl chloride and alkenyl boronic esters bearing chiral alcohols to give cyclopentyl intermediates bearing 3 contiguous stereocenters.

Jun 27, 2024 | digitalcommons.library.tmc.edu | Laura Cunningham |Sourabh Mishra |Leon Matthews |Stephen Fletcher

We report a general, catalyst-controlled route to prostaglandin F2α and its analogues. The approach uses a Rh-catalyzed dynamic kinetic asymmetric Suzuki–Miyaura coupling reaction between a racemic bicyclic allyl chloride and alkenyl boronic esters bearing chiral alcohols to give cyclopentyl intermediates bearing 3 contiguous stereocenters.