Leonid A. Uroshlev

Mar 6, 2023 | nature.com | Karen Sosa |Leonid A. Uroshlev |Noah Shriever |Artem S. Kasianov |Thomas Carney |Andrea Rocco | +1 more

AbstractNeural crest cells are highly multipotent stem cells, but it remains unclear how their fate restriction to specific fates occurs. The direct fate restriction model hypothesises that migrating cells maintain full multipotency, whilst progressive fate restriction envisages fully multipotent cells transitioning to partially-restricted intermediates before committing to individual fates.