Levi Gadye

Oakland

Health and Science Writer, UCSF School of Pharmacy at Freelance

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Articles

How Do Middle-Aged Folks Get Dementia? It Could Be These Proteins

3 weeks ago | ucsf.edu | Levi Gadye

Dementia usually affects older people, so when it occurs in middle age, it can be hard to recognize. The most common form is frontotemporal dementia (FTD), which is often mistaken for depression, schizophrenia, or Parkinson’s disease before the correct diagnosis is reached. Now, as part of an NIH-funded study, researchers at UC San Francisco have found some clues about how FTD develops that could lead to new diagnostics and get more patients into clinical trials.
UCSF Scientist Receives High Honor for Exceptional Career

1 month ago | ucsf.edu | Levi Gadye

UC San Francisco researcher and campus leader Atul Butte, MD, PhD, has been recognized for his outstanding career in the computational and health sciences with induction into the American Academy of Arts and Sciences, one of the most prestigious and oldest honor societies in the U.S.Butte is a renowned biomedical and bioinformatics scientist who has spent his career applying computation to some of the most pressing challenges in disease diagnosis, therapeutics, and biomedicine.
Could this molecule be 'checkmate' for coronaviruses like SARS-CoV-2?

1 month ago | medicalxpress.com | Levi Gadye

A team at UC San Francisco and Gladstone Institutes has developed new drug candidates that show great promise against the virus that causes COVID-19 and potentially other coronaviruses that could cause future pandemics. In preclinical testing, the compounds performed better than Paxlovid against SARS-CoV-2 and the Middle East Respiratory Syndrome (MERS) virus, which periodically causes deadly outbreaks around the world.
Could this Molecule be ‘Checkmate’ for Coronaviruses like SARS-CoV-2?

1 month ago | ucsf.edu | Levi Gadye

From virtual to real-world drug candidatesThree years ago, the UCSF AViDD grant supercharged the efforts of the UCSF Quantitative Biosciences Institute (QBI) Coronavirus Research Group (QCRG). QCRG, which was founded in 2020 by QBI’s director, Nevan Krogan, PhD, brought together 800 scientists from more than 40 institutions across the world.
How to prime tumors to be defeated by cancer immunotherapy

1 month ago | medicalxpress.com | Levi Gadye

One of the best ways to defeat cancer is by rousing the immune system to attack it. Experts have thought that immune cells had to be inside of tumors for one type of immunotherapy, known as checkpoint inhibitors, to work. But new research from UCSF shows otherwise—creating the possibility that a wider range of tumors could be treated with immune-stimulating drugs.
Here’s How to Prime Tumors to be Defeated by Cancer Immunotherapy

1 month ago | ucsf.edu | Levi Gadye

One of the best ways to defeat cancer is by rousing the immune system to attack it. Experts have thought that immune cells had to be inside of tumors for one type of immunotherapy, known as checkpoint inhibitors, to work. But new research from UCSF shows otherwise – creating the possibility that a wider range of tumors could be treated with immune-stimulating drugs.
50 Years of Discovery and Influence on the Culture of Science

2 months ago | ucsf.edu | Levi Gadye

After a storied scientific career that began with the discovery of how hormones control genes, Keith Yamamoto, PhD, has retired. Yamamoto, who most recently served as Vice Chancellor for Science Policy and Strategy at UCSF, is best known for his role in developing the concept of precision medicine, which he laid out in a report along with colleagues at the National Academies of Sciences, Engineering, and Medicine. Precision medicine was just one of his many contributions to science policy.
Researchers learn how a drug called zotatifin kills cancer cells

2 months ago | medicalxpress.com | Levi Gadye

Swirling inside every cell are millions of microscopic messages called messenger RNAs (mRNAs). The messages are the genetic blueprints for proteins, which determine the behavior and health of the cell. All mRNAs are packaged to ensure they're only used at the right place and timeâ€”imagine notes sealed in envelopes. But in cancer, enzymes called helicases relentlessly unseal thousands of mRNAs, leading to out-of-control protein production.
Researchers Learn How a Drug Called Zotatifin Kills Cancer Cells

2 months ago | ucsf.edu | Levi Gadye

Swirling inside every cell are millions of microscopic messages called messenger RNAs (mRNAs). The messages are the genetic blueprints for proteins, which determine the behavior and health of the cell. All mRNAs are packaged to ensure they’re only used at the right place and time – imagine notes sealed in envelopes. But in cancer, enzymes called helicases relentlessly unseal thousands of mRNAs, leading to out-of-control protein production.
The ‘Silent’ X Chromosome Gives the Aging Female Brain a Boost

Mar 4, 2025 | ucsf.edu | Levi Gadye

UCSF researchers may have discovered how the female brain remains resilient in aging, answering an age-old question of how most women outlive men and retain their cognitive abilities longer. Females carry two X chromosomes. One of them is ensconced in a corner in the cell called the Barr body, where it can’t express many genes, and scientists thought it didn’t do much of anything.