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2 weeks ago | 
ucsf.edu | Levi Gadye
UC San Francisco researcher and campus leader Atul Butte, MD, PhD, has been recognized for his outstanding career in the computational and health sciences with induction into the American Academy of Arts and Sciences, one of the most prestigious and oldest honor societies in the U.S.Butte is a renowned biomedical and bioinformatics scientist who has spent his career applying computation to some of the most pressing challenges in disease diagnosis, therapeutics, and biomedicine.
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2 weeks ago | 
medicalxpress.com | Levi Gadye
A team at UC San Francisco and Gladstone Institutes has developed new drug candidates that show great promise against the virus that causes COVID-19 and potentially other coronaviruses that could cause future pandemics. In preclinical testing, the compounds performed better than Paxlovid against SARS-CoV-2 and the Middle East Respiratory Syndrome (MERS) virus, which periodically causes deadly outbreaks around the world.
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3 weeks ago | 
ucsf.edu | Levi Gadye
From virtual to real-world drug candidatesThree years ago, the UCSF AViDD grant supercharged the efforts of the UCSF Quantitative Biosciences Institute (QBI) Coronavirus Research Group (QCRG). QCRG, which was founded in 2020 by QBI’s director, Nevan Krogan, PhD, brought together 800 scientists from more than 40 institutions across the world.
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4 weeks ago | 
medicalxpress.com | Levi Gadye
One of the best ways to defeat cancer is by rousing the immune system to attack it. Experts have thought that immune cells had to be inside of tumors for one type of immunotherapy, known as checkpoint inhibitors, to work. But new research from UCSF shows otherwise—creating the possibility that a wider range of tumors could be treated with immune-stimulating drugs.
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4 weeks ago | 
ucsf.edu | Levi Gadye
One of the best ways to defeat cancer is by rousing the immune system to attack it. Experts have thought that immune cells had to be inside of tumors for one type of immunotherapy, known as checkpoint inhibitors, to work. But new research from UCSF shows otherwise – creating the possibility that a wider range of tumors could be treated with immune-stimulating drugs.
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1 month ago | 
ucsf.edu | Levi Gadye
After a storied scientific career that began with the discovery of how hormones control genes, Keith Yamamoto, PhD, has retired. Yamamoto, who most recently served as Vice Chancellor for Science Policy and Strategy at UCSF, is best known for his role in developing the concept of precision medicine, which he laid out in a report along with colleagues at the National Academies of Sciences, Engineering, and Medicine. Precision medicine was just one of his many contributions to science policy.
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1 month ago | 
medicalxpress.com | Levi Gadye
Swirling inside every cell are millions of microscopic messages called messenger RNAs (mRNAs). The messages are the genetic blueprints for proteins, which determine the behavior and health of the cell. All mRNAs are packaged to ensure they're only used at the right place and time—imagine notes sealed in envelopes. But in cancer, enzymes called helicases relentlessly unseal thousands of mRNAs, leading to out-of-control protein production.
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1 month ago | 
ucsf.edu | Levi Gadye
Swirling inside every cell are millions of microscopic messages called messenger RNAs (mRNAs). The messages are the genetic blueprints for proteins, which determine the behavior and health of the cell. All mRNAs are packaged to ensure they’re only used at the right place and time – imagine notes sealed in envelopes. But in cancer, enzymes called helicases relentlessly unseal thousands of mRNAs, leading to out-of-control protein production.
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2 months ago | 
ucsf.edu | Levi Gadye
UCSF researchers may have discovered how the female brain remains resilient in aging, answering an age-old question of how most women outlive men and retain their cognitive abilities longer. Females carry two X chromosomes. One of them is ensconced in a corner in the cell called the Barr body, where it can’t express many genes, and scientists thought it didn’t do much of anything.
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2 months ago | 
ucsf.edu | Laura Kurtzman |Levi Gadye
UC San Francisco received $815 million in awards from the National Institutes of Health (NIH) last year for research that will improve the lives of patients in the U.S. and around the world. The grants enable UCSF scientists to test new treatments for dementia and stroke, investigate the environmental causes of cancer and look for new ways to treat the world’s number one infectious disease killer, tuberculosis, which is becoming increasingly resistant to drugs.
