Lifan Lin

Jul 17, 2024 | onlinelibrary.wiley.com | Qing Chen |Bin Peng |Lifan Lin |Jiawen Chen

1 Introduction Colorectal cancer (CRC) is one of the most common malignant tumors worldwide, causing nearly 1.85 million illnesses and 850000 deaths each year.[1, 2] Because most patients with CRC do not have obvious symptoms in the early stages, approximately 80% are already in advanced stages when diagnosed.[3] Patients with advanced CRC depend on palliative treatments primarily based on chemotherapy, but tumor resistance to chemotherapeutic drugs is common.[4, 5] Therefore, effective...