Lihua Wang

Jun 14, 2024 | nejm.org | Lihua Wang |Liyuan Wang

AbstractTenecteplase is an effective thrombolytic agent for eligible patients with stroke who are treated within 4.5 hours after the onset of stroke. However, data regarding the effectiveness of tenecteplase beyond 4.5 hours are limited.

Jun 14, 2024 | nejm.org | Lihua Wang |Liyuan Wang

AbstractTenecteplase is an effective thrombolytic agent for eligible patients with stroke who are treated within 4.5 hours after the onset of stroke. However, data regarding the effectiveness of tenecteplase beyond 4.5 hours are limited.

May 30, 2024 | nature.com | Shihong M Gao |Yanyan Qi |Qinghao Zhang |Youchen Guan |Lang Ding |Lihua Wang | +5 more

Organismal aging involves functional declines in both somatic and reproductive tissues. Multiple strategies have been discovered to extend lifespan across species. However, how age-related molecular changes differ among various tissues and how those lifespan-extending strategies slow tissue aging in distinct manners remain unclear. Here we generated the transcriptomic Cell Atlas of Worm Aging (CAWA, http://mengwanglab.org/atlas ) of wild-type and long-lived strains. We discovered cell-specific, age-related molecular and functional signatures across all somatic and germ cell types. We developed transcriptomic aging clocks for different tissues and quantitatively determined how three different pro-longevity strategies slow tissue aging distinctively. Furthermore, through genome-wide profiling of alternative polyadenylation (APA) events in different tissues, we discovered cell-type-specific APA changes during aging and revealed how these changes are differentially affected by the pro-longevity strategies. Together, this study offers fundamental molecular insights into both somatic and reproductive aging and provides a valuable resource for in-depth understanding of the diversity of pro-longevity mechanisms. This comprehensive resource offers new insights into how different types of cell and tissue change with age in C. elegans and unveils the distinctive anti-aging effects of various pro-longevity strategies in a cell-type-specific manner.

Oct 13, 2023 | mdpi.com | Quang Lam Truong |Lihua Wang |Tuan Nguyen |Hoa Nguyen |Hoa Nguyễn

This is an early access version, the complete PDF, HTML, and XML versions will be available soon.

Sep 14, 2023 | nature.com | Jun Ding |Lihua Wang

AbstractNanosized metals usually exhibit ultrahigh strength but suffer from low homogeneous plasticity. The origin of a strength–ductility trade-off has been well studied for pure metals, but not for random solid solution (RSS) alloys. How RSS alloys accommodate plasticity and whether they can achieve synergy between high strength and superplasticity has remained unresolved.