Lika Drakhlis

Oct 8, 2024 | nature.com | Miriana Dardano |Axel Schambach |Lika Drakhlis

AbstractDespite the biomedical importance of haematopoietic stem cells and haematopoietic progenitor cells, their in vitro stabilization in a developmental context has not been achieved due to limited knowledge of signals and markers specifying the multiple haematopoietic waves as well as ethically restricted access to the human embryo. Thus, an in vitro approach resembling aspects of haematopoietic development in the context of neighbouring tissues is of interest.

Mar 28, 2024 | nature.com | Kevin Ullmann |Felix Manstein |Lika Drakhlis |Ulrich Martin |Nils Kriedemann |Alexandra Haase

AbstractA promising cell-therapy approach for heart failure aims at differentiating human pluripotent stem cells (hPSCs) into functional cardiomyocytes (CMs) in vitro to replace the disease-induced loss of patients’ heart muscle cells in vivo. But many challenges remain for the routine clinical application of hPSC-derived CMs (hPSC-CMs), including good manufacturing practice (GMP)-compliant production strategies.