Lili Zhu

Nov 25, 2024 | nature.com | Lili Zhu

AbstractBRCA1-associated protein 1 (BAP1) acts as a tumor suppressor and can affect the cell cycle, tumor immunity, and cellular metabolism through multiple pathways. In melanoma, BAP1 mutations promote tumor cell glycolysis, leading to increased lactate production. The tumor microenvironment with high lactate levels is often associated with immunosuppression and tumor progression.

Aug 8, 2024 | onlinelibrary.wiley.com | Feng Peng |Lili Zhu |Jiang Lan Fan

Lovastatin, a type of statin usually considered as a lipid-lowering drug that lowers blood cholesterol and low-density lipoprotein cholesterol levels, has been rediscovered to have anticancer activity. Fewer studies exist regarding the effect of lovastatin on esophageal squamous cell carcinoma (ESCC). Here, we report that lovastatin shows anticancer effect on ESCC By affecting the mitochondrial autophagy pathway.

Jun 14, 2023 | nature.com | Jianping Guo |Huiying Wang |Wei Guan |Qin Guo |Jing L. Wang |Jing Yang | +18 more

AbstractPlants deploy receptor-like kinases and nucleotide-binding leucine-rich repeat receptors to confer host plant resistance (HPR) to herbivores1. These gene-for-gene interactions between insects and their hosts have been proposed for more than 50 years2. However, the molecular and cellular mechanisms that underlie HPR have been elusive, as the identity and sensing mechanisms of insect avirulence effectors have remained unknown.