Lilly M. Wong

Jun 15, 2023 | jci.org | Yuyang Tang |Antoine Chaillon |Sara Gianella |Lilly M. Wong

AbstractBrain microglia (MG) may serve as a human immunodeficiency virus 1 (HIV) reservoir and ignite rebound viremia following cessation of antiretroviral therapy (ART), but they have yet to be proven to harbor replication-competent HIV. Here, we isolated brain myeloid cells (BrMCs) from nonhuman primates and rapid autopsy of people with HIV (PWH) on ART and sought evidence of persistent viral infection.