Lingegowda S. Mangala

Oct 3, 2024 | digitalcommons.library.tmc.edu | David Jensen |Peng Han |Lingegowda S. Mangala |Gabriel Lopez-Berestein

AbstractMicroRNA miR-29 promotes endothelial function in human arterioles in part by targeting LYPLA1 and increasing nitric oxide production. In addition, miR-29 is a master inhibitor of extracellular matrix gene expression, which may attenuate fibrosis but could also weaken tissue structure. The goal of this study was to test whether miR-29 could be developed as an effective, broad-acting, and safe therapeutic.