Lingjie Sang

Jan 9, 2025 | nature.com | Chengyu Shi |Shanshan Xie |Qiang Sun |Lingjie Sang |Wei Zhuo |Jian Liu | +8 more

AbstractThe systematic identification and functional characterization of noncanonical translation products, such as novel peptides, will facilitate the understanding of the human genome and provide new insights into cell biology. Here, we constructed a high-coverage peptide sequencing reference library with 11,668,944 open reading frames and employed an ultrafiltration tandem mass spectrometry assay to identify novel peptides.

Apr 28, 2023 | frontiersin.org | Xiao Xiao |Lingjie Sang |Hao Wu

1. IntroductionStroke remains one of the leading causes of death worldwide and is associated with an extremely high rate of disability (Organization, G.W.H., 2022). Intracerebral hemorrhage (ICH) accounts for approximately 27.9% of all strokes, with a higher mortality than that of ischemic stroke (GBD 2019 Stroke Collaborators, 2021). Especially the mortality is as high as 30–40% in acute and subacute phases (Greenberg et al., 2022).