Lonnie Shea

Mar 17, 2024 | nature.com | Katja M. Piltti |Kiran Pawar |Lonnie Shea |Brian Cummings |Usha Nekanti |Rebecca A. Nishi

AbstractRegeneration in the injured spinal cord is limited by physical and chemical barriers. Acute implantation of a multichannel poly(lactide-co-glycolide) (PLG) bridge mechanically stabilizes the injury, modulates inflammation, and provides a permissive environment for rapid cellularization and robust axonal regrowth through this otherwise inhibitory milieu. However, without additional intervention, regenerated axons remain largely unmyelinated (<10%), limiting functional repair.