Lori C. Sakoda

Sep 21, 2024 | acsjournals.onlinelibrary.wiley.com | Leah Backhus |Ching-Fei Chang |Lori C. Sakoda |Shonta R. Chambers

INTRODUCTION Lung cancer is the third most commonly diagnosed cancer and the second leading cause of cancer death among females worldwide, with an estimated 770,828 cases and 607,465 deaths in 2020.1 Global incidence and mortality rates vary by more than 20-fold, with the 2020 age-standardized incidence rates per 100,000 females ranging from approximately one in many African and Middle Eastern countries to 35.0 in Hungary.2 Cigarette smoking contributes to nearly 40% of lung cancer deaths...

Oct 2, 2023 | nature.com | Minta Thomas |Elisabeth Rosenthal |Lori C. Sakoda |Stephanie Schmit |Maria Timofeeva |Ceres Fernández-Rozadilla | +60 more

AbstractPolygenic risk scores (PRS) have great potential to guide precision colorectal cancer (CRC) prevention by identifying those at higher risk to undertake targeted screening. However, current PRS using European ancestry data have sub-optimal performance in non-European ancestry populations, limiting their utility among these populations.

Oct 2, 2023 | nature.com | Minta Thomas |Elisabeth Rosenthal |Lori C. Sakoda |Stephanie Schmit |Maria Timofeeva |Ceres Fernández-Rozadilla | +60 more

AbstractPolygenic risk scores (PRS) have great potential to guide precision colorectal cancer (CRC) prevention by identifying those at higher risk to undertake targeted screening. However, current PRS using European ancestry data have sub-optimal performance in non-European ancestry populations, limiting their utility among these populations.