Louise Reilly

Jan 17, 2024 | cell.com | Jacqueline Howie |Elaine Chukan Brown |Louise Reilly |Lindsay B. Tulloch

Highlights•Identify peroxiredoxin 6 (Prdx6) as a thioesterase•Protein depalmitoylation by Prdx6 occurs via its catalytic cysteine•Phospholemman depalmitoylation by Prdx6 is glutathione dependent•Prdx6 thioesterase activity confers redox sensitivity on the Na pumpSummaryPhospholemman (PLM) regulates the cardiac sodium pump: PLM phosphorylation activates the pump whereas PLM palmitoylation inhibits its activity.

Jan 17, 2024 | cell.com | Jacqueline Howie |Elaine Chukan Brown |Louise Reilly |Lindsay B. Tulloch

Highlights•Identify peroxiredoxin 6 (Prdx6) as a thioesterase•Protein depalmitoylation by Prdx6 occurs via its catalytic cysteine•Phospholemman depalmitoylation by Prdx6 is glutathione dependent•Prdx6 thioesterase activity confers redox sensitivity on the Na pumpSummaryPhospholemman (PLM) regulates the cardiac sodium pump: PLM phosphorylation activates the pump whereas PLM palmitoylation inhibits its activity.