Louise S. Matheson

Dec 5, 2024 | biorxiv.org | Fiamma Salerno |Alex Whale |Louise S. Matheson |William Foster

AbstractHow germinal centre (GC) B cells undergo rapid cell division while maintaining genome stability is poorly understood. Here, we show that the RNA-binding proteins ZFP36L1 and ZFP36L2 act downstream of antigen-sensing and protect GC B cells from replication stress by controlling a cell cycle-related RNA post-transcriptional regulon.