Lovedeep S Dhingra

May 8, 2024 | nature.com | Arya Aminorroaya |Lovedeep S Dhingra |Evangelos Oikonomou |Sumukh Vasisht Shankar

AbstractElevated lipoprotein (a) (Lp(a)) is associated with premature atherosclerotic cardiovascular disease. However, fewer than 0.5% of individuals undergo Lp(a) testing, limiting the evaluation and use of novel targeted therapeutics currently under development. Here we describe the development of a machine learning model for targeted screening for elevated Lp(a) (≥150 nmol l−1) in the UK Biobank (N = 456,815), the largest cohort with protocolized Lp(a) testing.