Lu O. Sun

Dec 19, 2024 | nature.com | Zhaoling Li |Lu O. Sun |Runsen Zhang |Tatsuya Hanaoka

The cement industry plays a key role in emission reduction efforts, but cement quality is rarely considered in low-carbon development analyses. Here we design three cement quality transformation routes in response to China’s cement quality improvement program and analyse the corresponding low-carbon development pathways via a bottom-up integrated assessment model. Results show that cement quality improvements trigger a 14.6% increase in energy consumption and emissions in business-as-usual scenarios in 2060. Compared with the base year, raising the environmental taxes to 46.8 Chinese Yuan per equivalent unit saves up to 75.1% of carbon dioxide emissions and 25.0% of fuel consumption from the high-quality-cement scenario by 2060. Carbon capture and storage contributes up to 77% of the emission reduction. The reduction in cement demand conserves 17.3% more energy than the high-cement-demand scenario does in 2060. Collaborative waste treatment is expected to replace 22.4% of fuel consumption in the cement industry in 2060. In China, under the high cement quality scenario, the increase of environmental taxes is projected to reduce carbon dioxide emissions and fuel consumption in the cement industry by 2060, according to an analysis that uses an integrated assessment model with the flow of energy and materials.

Jun 26, 2024 | nature.com | Lu O. Sun |Xiang Zhou |Jie Yang

AbstractA long-standing but poorly tested hypothesis in plant ecology and evolution is that biotic interactions play a more important role in producing and maintaining species diversity in the tropics than in the temperate zone. A core prediction of this hypothesis is that tropical plants deploy a higher diversity of phytochemicals within and across communities because they experience more herbivore pressure than temperate plants.

May 8, 2024 | nature.com | Richard Everson |Willy Hugo |Lu O. Sun |Joseph K. Antonios |Melissa Bu |Sara Khattab | +9 more

In this randomized phase II clinical trial, we evaluated the effectiveness of adding the TLR agonists, poly-ICLC or resiquimod, to autologous tumor lysate-pulsed dendritic cell (ATL-DC) vaccination in patients with newly-diagnosed or recurrent WHO Grade III-IV malignant gliomas. The primary endpoints were to assess the most effective combination of vaccine and adjuvant in order to enhance the immune potency, along with safety. The combination of ATL-DC vaccination and TLR agonist was safe and found to enhance systemic immune responses, as indicated by increased interferon gene expression and changes in immune cell activation. Specifically, PD-1 expression increases on CD4+ T-cells, while CD38 and CD39 expression are reduced on CD8+ T cells, alongside an increase in monocytes. Poly-ICLC treatment amplifies the induction of interferon-induced genes in monocytes and T lymphocytes. Patients that exhibit higher interferon response gene expression demonstrate prolonged survival and delayed disease progression. These findings suggest that combining ATL-DC with poly-ICLC can induce a polarized interferon response in circulating monocytes and CD8+ T cells, which may represent an important blood biomarker for immunotherapy in this patient population.Trial Registration: ClinicalTrials.gov Identifier: NCT01204684. Autologous tumor lysate (ATL) dendritic cell (DC) vaccination can induce local and systemic anti-tumor immune responses in malignant glioma patients. In this randomized phase II clinical trial, the authors evaluate the effectiveness of adding the TLR agonists, poly-ICLC or resiquimod, to ATL-DC vaccination in patients with newly-diagnosed or recurrent WHO Grade III-IV malignant gliomas.

Apr 23, 2024 | pubs.rsc.org | Fanqi Meng |Lu O. Sun |Yueying Liu |Xiang Li

Theoretical investigation of the reaction mechanism of THP oxidative rearrangement catalysed by BBOX γ-butyrobetaine hydroxylase (BBOX) is a non-heme FeII/2OG dependent enzyme that is able to perform two different kinds of catalytic reactions on 3-(2,2,2-trimethylhydrazinium) propionate (THP) to produce distinct catalytic products. Although the structure of BBOX complexed with THP has been resolved, the details of its catalytic mechanism are still elusive.