Luc Lederer

Jan 3, 2025 | cell.com | Jing Xie |Javad Najafi |Aude Nommick |Luc Lederer |Jeremy Sallé |Serge Dmitrieff | +3 more

Keywordscell divisioncell shapeembryogenesismitotic spindlesforcescytoplasmflowsGet full text accessLog in, subscribe or purchase for full access. References1. Sallé, J. ∙ Minc, N. Cell division geometries as central organizers of early embryo developmentSemin. Cell Dev. Biol. 2022; 130:3-112. Godard, B.G. ∙ Heisenberg, C.-P. Cell division and tissue mechanicsCurr. Opin. Cell Biol. 2019; 60:114-1203. Lechler, T. ∙ Mapelli, M.

Jun 3, 2024 | biorxiv.org | Jing Xie |Javad Najafi |Aude Nommick |Luc Lederer

AbstractCell geometry is a key parameter for the regulation of mitotic spindle positioning during early embryo development and tissue morphogenesis. To date, however, we still lack an understanding for how intracellular forces that position, orient or hold mitotic spindles depend on cell geometry. Here, we used in vivo magnetic tweezers to directly measure the forces that maintain the mitotic spindle in the center of sea urchin cells that adopt different shapes during early embryo development.

Dec 15, 2023 | biorxiv.org | Jing Xie |Javad Najafi |Aude Nommick |Luc Lederer

AbstractCell geometry is an important element in the regulation of mitotic spindle positioning during early embryo development and tissue morphogenesis. To date, however, we still lack an understanding for how intracellular forces that position and stabilize mitotic spindles depend on cell geometry.