Lucija Klaric

Oct 21, 2024 | nature.com | Shona M. Kerr |Lucija Klaric |Emma Cowan |Zosia Miedzybrodzka

AbstractFor breast and ovarian cancer risk assessment in the isolated populations of the Northern Isles of Orkney and Shetland (in Scotland, UK) and their diasporas, quantifying genetically drifted BRCA1 and BRCA2 pathogenic variants is important. Two actionable variants in these genes have reached much higher frequencies than in cosmopolitan UK populations. Here, we report a BRCA2 splice acceptor variant, c.517-2A>G, found in breast and ovarian cancer families from Shetland.

Apr 6, 2024 | medrxiv.org | Shona M. Kerr |Lucija Klaric |Emma Cowan |Marisa D. Muckian

AS and GT are employees and/or stockholders of Regeneron Genetics Center or Regeneron Pharmaceuticals. This study was funded by the MRC University Unit award to the MRC Human Genetics Unit, University of Edinburgh, MC_UU_00007/10 and a Wellcome Trust Institutional Translational Partnership Award (University of Edinburgh 222060/Z/20/Z -PIII031). LK was supported by an RCUK Innovation Fellowship from the National Productivity Investment Fund (MR/R026408/1).

Oct 26, 2023 | flipboard.com | Jordan Bortz |Lucija Klaric |Peter Ward |Michael Geer |Marc Chadeau-Hyam |Dragana Vuckovic | +2 more

1 day agoThis is the sad truth. When scientists realized that nearly 10 billion snow crabs had gone missing from Bering Sea between 2018 to 2021, they weren’t sure where they could have gone. After searching for a potentially migrating population, however, they came to a much more unfortunate conclusion. A new …

Jul 11, 2023 | nature.com | Erola Pairo-Castineira |Konrad Rawlik |Andrew Bretherick |Yang Wu |Lucija Klaric |Tomas Malinauskas | +22 more

Correction to: Nature https://doi.org/10.1038/s41586-023-06034-3 Published online 17 May 2023In the version of this article initially published, the name of Ana Margarita Baldión-Elorza, of the SCOURGE Consortium, appeared incorrectly (as Ana María Baldion) and has now been amended in the HTML and PDF versions of the article.

May 17, 2023 | nature.com | Erola Pairo-Castineira |Konrad Rawlik |Andrew Bretherick |Yang Wu |Lucija Klaric |Tomas Malinauskas | +22 more

Hospitalization meta-analysisThe hospitalized phenotype includes patients who were hospitalized with a laboratory-confirmed SARS-Cov2 infection. In this analysis we included GenOMICC, GenOMICC Brazil, GenOMICC Saudi Arabia, ISARIC4C, HGIv6 B2 phenotype with subtraction of GenOMICC data, SCOURGE hospitalized versus population and mild cases, and 23andMe broad respiratory phenotype.