Lucy Hezinger

Jul 24, 2023 | febs.onlinelibrary.wiley.com | Lucy Hezinger |Sarah Bauer |Kornelia Ellwanger |Alban Piotrowsky

NOD1 and HAX-1 affect cell migration independently of RIPK2 and NF-κB activation NOD1 overexpression in our HeLa NOD1-eGFP cells induces NF-κB activation [[42]] via RIPK2 and most NOD1-mediated effects require RIPK2 signalling [[43]]. However, also RIPK2 independent signalling of NOD1 has been described, such as for the induction of autophagy in some cells [[44]].

May 11, 2023 | mdpi.com | Sarah Bauer |Fjolla Rexhepi |Sheela Ramanathan |Lucy Hezinger

Abstract:Obesity and its associated metabolic morbidities have been and still are on the rise, posing a major challenge to health care systems worldwide. It has become evident over the last decades that a low-grade inflammatory response, primarily proceeding from the adipose tissue (AT), essentially contributes to adiposity-associated comorbidities, most prominently insulin resistance (IR), atherosclerosis and liver diseases.