Luis M. Molinos-Albert

Oct 10, 2023 | nature.com | Luis M. Molinos-Albert |Pierre Rosenbaum |Thierry Hieu |Dominique Clermont |Jordan Dimitrov |Sophie Hue | +1 more

AbstractHIV-1 infection causes severe alterations of gut mucosa, microbiota and immune system, which can be curbed by early antiretroviral therapy. Here, we investigate how treatment timing affects intestinal memory B-cell and plasmablast repertoires of HIV-1-infected humans. We show that only class-switched memory B cells markedly differ between subjects treated during the acute and chronic phases of infection.