Luis Tavernelli

Jul 19, 2024 | journals.asm.org | Luis Tavernelli |V. Alonso

INTRODUCTIONTrypanosoma cruzi is a unicellular parasite that causes Chagas Disease (also known as American trypanosomiasis). It is estimated that at least 6 million people are infected globally and around 12,000 deaths occur annually because of this illness. In the Americas, Chagas disease is the most common parasitic disease, with an annual incidence of 30,000 new cases on average; among them, 8,600 are newborns that become infected during pregnancy (1).

Feb 18, 2024 | biorxiv.org | Esteban SERRA |V. Alonso |Luis Tavernelli |Imanol Peña

AbstractBromodomains are structural folds present in all eukaryotic cells that bind to other proteins recognizing acetylated lysines. Most proteins with bromodomains are part of nuclear complexes that interact with acetylated histone residues and participate in regulating DNA replication, transcription, and repair through chromatin structure remodeling.