Lukas Beumers

Dec 1, 2023 | nature.com | Lukas Beumers |Efstathios-Iason Vlachavas |Luisa Schwarzmüller |Birgitta E. Michels |Emre Sofyali |Yosef Yarden | +2 more

AbstractIntratumoral heterogeneity impacts the success or failure of anti-cancer therapies. Here, we investigated the evolution and mechanistic heterogeneity in clonal populations of cell models for estrogen receptor positive breast cancer. To this end, we established barcoded models of luminal breast cancer and rendered them resistant to commonly applied first line endocrine therapies.