Lyndell L Lim

Feb 22, 2024 | onlinelibrary.wiley.com | Priya D Samalia |Lyndell L Lim |Rachael L. Niederer

CONFLICT OF INTEREST STATEMENT The authors declare no conflict of interest. REFERENCES 1, , , . Sarcoidosis. J Fr Ophthalmol. 2018; 41(10): e451-e467. 2, , . Ocular sarcoidosis: new diagnostic modalities and treatment. Curr Opin Pulm Med. 2017; 23(5): 458-467. 3, , , , . Ocular sarcoidosis. Presse Med. 2012; 41(6 Pt 2): e349-e354. 4, , , et al. Sarcoidosis: a clinical overview from symptoms to diagnosis. Cell. 2021; 10(4): 766. 5, .

Aug 19, 2023 | nature.com | Lyndell L Lim

AbstractAutoimmunity and deficiency of the transcription factor autoimmune regulator protein (AIRE) are known associations with Down syndrome (DS). Lack of AIRE abrogates thymic tolerance. The autoimmune eye disease associated with DS has not been characterized. We identified a series of subjects with DS (n = 8) and uveitis. In three consecutive subjects, we tested the hypothesis that autoimmunity to retinal antigens might be a contributing factor. This was a multicentred, retrospective case series.