Manja Idorn

Jul 24, 2024 | nature.com | Manja Idorn |Manutea C. Serrero |Xiaoyong Pan |Emil A. Thomsen |Ryo Narita |Muwan Chen | +7 more

AbstractThe brain is highly sensitive to damage caused by infection and inflammation1,2. Herpes simplex virus 1 (HSV-1) is a neurotropic virus and the cause of herpes simplex encephalitis3. It is unknown whether neuron-specific antiviral factors control virus replication to prevent infection and excessive inflammatory responses, hence protecting the brain. Here we identify TMEFF1 as an HSV-1 restriction factor using genome-wide CRISPR screening.