Manon Kappelhof

Jun 9, 2023 | frontiersin.org | Maurizio Acampa |Manon Kappelhof |Zhenhui Duan

1 IntroductionIn 2015, results from five randomized controlled trials (RCT) established endovascular therapy (EVT) as the optimal treatment for acute ischemic stroke (AIS) involving large vessel occlusion (LVO), provided that it was performed within an effective time window. Specifically, the MR CLEAN, EXTEND-IA, and SWIFT PRIM trials were conducted within 6 h of stroke onset (1–3), while the REVASCAT trial was conducted within 8 h (4), and the ESCAPE trial within 12 h (5).