Marc Payton

Dec 27, 2023 | nature.com | Marc Payton |Andrew Boghossian |Matthew Rees |Melissa Ronan |Jennifer Roth

AbstractChromosomal instability (CIN) is a hallmark of cancer, caused by persistent errors in chromosome segregation during mitosis. Aggressive cancers like high-grade serous ovarian cancer (HGSOC) and triple-negative breast cancer (TNBC) have a high frequency of CIN and TP53 mutations. Here, we show that inhibitors of the KIF18A motor protein activate the mitotic checkpoint and selectively kill chromosomally unstable cancer cells.