Marcel Tuppi

Jan 9, 2025 | nature.com | Philipp Münick |Alexander Strubel |Dimitrios-Ilias Balourdas |Julianne Funk |Marcel Tuppi |Busra Yuksel | +4 more

AbstractInfection of cells with high-risk strains of the human papillomavirus (HPV) causes cancer in various types of epithelial tissue. HPV infections are responsible for ~4.5% of all cancers worldwide. Tumorigenesis is based on the inactivation of key cellular control mechanisms by the viral proteins E6 and E7. The HPV E6 protein interacts with the cellular E3 ligase E6AP, and this complex binds to the p53 DNA-binding domain, which results in degradation of p53.