Margeaux Capron

Mar 18, 2024 | aiche.onlinelibrary.wiley.com | Abigail King |Yiwei Zhao |Alexandru Lazar |Margeaux Capron

1 INTRODUCTION Biologics drug products are often produced via a cell-based expression system, which may originate from one of the many kingdoms of life (bacteria, yeast, mammal, plant, etc.). As a result, some biological materials from the host cells are secreted and may be co-purified with a given drug product. One category of such impurity is host cell proteins (HCPs).