Maria Jarvis

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Immune Profiling of Adeno-Associated Virus Response Identifies B Cell-Specific Targets That Enable Vector Re-Administration in Mice

Jan 21, 2025 | digitalcommons.library.tmc.edu | Maria Chen |Boram Kim |Maria Jarvis |Samantha T. Fleury

KeywordsAnimals, Mice, Dependovirus, Gene Transfer Techniques, Genetic Therapy, Immunoglobulin M, Genetic Vectors, Adeno-associated viruses, Vectors, Gene delivery, Immunotherapy, Blood-brain barrier, Brain delivery, ImmunogenicityAbstractAdeno-associated virus (AAV) vector-based gene therapies can be applied to a wide range of diseases. AAV expression can last for months to years, but vector re-administration may be necessary to achieve life-long treatment.

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