María José Sáez

Nov 21, 2024 | biorxiv.org | Javier Alegre-Cortés |Maurizio Mattia |Maria Saez |María Soledad Saez |María José Sáez |Ramon Reig

AbstractExplaining the macroscopic activity of a recorded neuronal population from its known microscopic properties still poses a great challenge, not just because of the many local agents that shape the output of a circuit, but due to the impact of long-range connections from other brain regions. Here we use a computational model to explore how local and global components of a network shape the Slow Wave Activity (SWA).

Sep 25, 2023 | biorxiv.org | Maria Saez |María Soledad Saez |María José Sáez |Cristina García-Frigola |Javier Alegre-Cortés |Nicolás A. Morgenstern

AbstractThe brain operates with simultaneous different sensory modalities in order to engage adaptive responses. However, the question of how (and where) multisensory information is integrated remains unanswered. In the dorsomedial striatum, single medium spiny neurons (MSNs) are excited by tactile and visual inputs; however, the mechanism which allows the integration of these responses and how they are shaped by dopamine is unknown.