María Noel Spangenberg

Sep 13, 2023 | frontiersin.org | Facultad de Medicina |Bioinformatics Unit |Departamento de Genetica |María Noel Spangenberg

1 IntroductionCommon variable immunodeficiency disorders (CVIDs) are a group of primary immunodeficiencies associated with impaired B-cell differentiation and defective primary antibody production (1). CVID is characterized by heterogeneous clinical manifestations including recurrent infections, chronic lung disease, autoimmune disorders, gastrointestinal diseases, and heightened susceptibility to lymphoma (2).