Marjolein Metselaar-Albers

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No detrimental association between antibiotic use and immune checkpoint inhibitor therapy: an observational cohort study comparing patients with ICI-treated and TKI-treated melanoma and NSCLC

Jan 1, 2024 | jitc.bmj.com | John B. Haanen |Marjolein Metselaar-Albers |Irma Meijerman |Ferdi Engels

Discussion and conclusionOur study suggests that antibiotic therapy at cancer treatment initiation does not detrimentally impact ICI therapy response in melanoma and NSCLC. The magnitude of decreased OS in antibiotic users was similar between individuals on ICI therapy (HR=1.28; 95% CI 1.07 to 1.52) and those on TKIs (HR=1.20; 95% CI 0.92 to 1.57; synergy index=0.96; 95% CI 0.71 to 1.31).

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