Mark Hester

Oct 23, 2023 | nature.com | Adithe C. Rivaldi |Noriyuki Shinagawa |Sahib Sran |Mark Hester |Mohammad Marhabaie |Manish Shah | +4 more

AbstractSomatic mosaicism is a known cause of neurological disorders, including developmental brain malformations and epilepsy. Brain mosaicism is traditionally attributed to post-zygotic genetic alterations arising in fetal development. Here we describe post-zygotic rescue of meiotic errors as an alternate origin of brain mosaicism in patients with focal epilepsy who have mosaic chromosome 1q copy number gains.

Apr 27, 2023 | theoregonway.substack.com | Mark Hester

The headline looked like clickbait when I saw it on social media: College graduates expect to earn $50,000 more than they’ll actually make. This time the sensational claim wasn’t clickbait; it was true – or close to it. The story was based on a 2022 survey of college students asking what they expected to make. The average answer: $103,800. The average annual pay for graduates in their first job: $55,000.

Mar 21, 2023 | theoregonway.substack.com | Mark Hester

There’s no shortage of opinions about what Portland needs to do to repair its damaged image, revive its stagnant economy, reclaim its downtrodden downtown and retain residents who are fleeing – or better yet once again become a city that attracts newcomers. When problems are this numerous and severe, the answer generally is “all of the above.” No one approach will be enough. And it certainly will take more than “cleaning up the trash,” one solution many people like to talk about.

Feb 15, 2023 | theoregonway.substack.com | Mark Hester

As regular readers of my columns know, I have significant disagreements with both major political parties. My reservations with the Democratic Party, of which I’m currently a member, are varied. No single issue stands out, though in general the party is at least a little left of me on most issues. But my disenchantment with the Republican Party, to which I’ve belonged most of my voting life, does revolve around a single issue: the party’s embrace of Christian nationalism.