Markus Engstler

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Structure-function analysis defines the minimal functional C-terminal domain of the variant surface glycoprotein of Trypanosoma brucei

2 weeks ago | jbc.org | Nicola Jones |Markus Engstler

Keywordscell surfacevariant surface glycoproteinstructure-functionmutagenesisprotein domainGlycosylphosphatidylinositol (GPI) anchorTrypanosoma bruceiTrypanosoma congolenseIntroductionThe bloodstream form of Trypanosoma brucei is covered by a homogenous, dense glycoprotein layer, which, at a given time, consists almost entirely of a single isoform of the large family of GPI-anchored variant surface glycoproteins (VSGs) (1-3).

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