Markus Ringnér

Apr 28, 2024 | nature.com | Roberta Filograna |Markus Ringnér |Sara Riggare |Per Svenningsson |Michela Barbaro

AbstractLoss-of-function variants in the PRKN gene encoding the ubiquitin E3 ligase PARKIN cause autosomal recessive early-onset Parkinson’s disease (PD). Extensive in vitro and in vivo studies have reported that PARKIN is involved in multiple pathways of mitochondrial quality control, including mitochondrial degradation and biogenesis. However, these findings are surrounded by substantial controversy due to conflicting experimental data.