Marta González-Sepúlveda

Oct 11, 2024 | nature.com | Ariadna Laguna |Nuria Penuelas |Marta González-Sepúlveda |Sébastien Arthaud |Joan Compte |Lluis Miquel-Rio | +8 more

AbstractOne key limitation in developing effective treatments for neurodegenerative diseases is the lack of models accurately mimicking the complex physiopathology of the human disease. Humans accumulate with age the pigment neuromelanin inside neurons that synthesize catecholamines. Neurons reaching the highest neuromelanin levels preferentially degenerate in Parkinson’s, Alzheimer’s and apparently healthy aging individuals.