Martin Grasshoff

Nov 19, 2024 | academic.oup.com | RWTH Aachen |Martin Grasshoff |Steffen Koschmieder

The development of single-cell RNA-sequencing (scRNA-seq) methods allows the characterization of transcriptional changes in yet poorly characterized cell types [1, 2]. This has been crucial to uncover cellular mechanisms related to diseases [3–6]. Clonal selection, i.e. the expansion of particular cell populations with malignant mutations, is a crucial mechanism in tumor cell development [7].